Epidemiology
Mutation patterns
TP53 is not mutated randomly. Specific cancer types carry disproportionately high mutation burdens, and missense mutations dominate overwhelmingly.
Mutations by Cancer Type
Total mutated samples per topography · NCI TP53 Database R21
Mutation Type Distribution
Percentage of all somatic TP53 mutations
74.1%
of all TP53 mutations are missense — a single amino acid change
80%+
of cancer mutations fall in the DNA Binding Domain (residues 98–292)
6
hotspot codons account for ~20% of all TP53 mutations in cancer
R175H
is the single most common TP53 mutation across all cancer types