Interactive Molecular Biology
The Guardian
of the Genome
TP53 is the most frequently mutated gene in human cancer — altered in over half of all solid tumor cases and present in roughly 29% of all cancer diagnoses globally. Explore its 3D structure, map every known mutation, and understand why it matters.
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50%+
of all cancers carry TP53 mutations
393
amino acids in the p53 protein
29,900+
tumor variants catalogued in NCI TP53 Database R21
46
years of research since p53 was discovered (1979)